Mechanical properties of porcine brain tissue in vivo and ex vivo estimated by MR elastography |
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| Institution: | 1. Washington University in St. Louis, Mechanical Engineering and Materials Science, United States;2. Washington University in St. Louis, Biomedical Engineering, United States;3. University of Delaware, Biomedical Engineering, United States;1. Department of Mechanical Engineering, Stanford University, Stanford CA 94305, USA;2. Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ, USA;3. Department of Radiology Stanford University, Stanford CA 94305, USA;4. Departments of Mechanical Engineering and Bioengineering, Stanford University, Stanford CA 94305, USA;1. School of Mechanical and Electronic Engineering, Soochow University, Suzhou 215021, Jiangsu, China;2. Robotics and Microsystems Center, Soochow University, Suzhou 215021, Jiangsu, China;3. School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, United States;4. Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX 78705, United States;5. Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, United States;1. Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States;2. Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, United States;3. Biomedical Engineering, University of Delaware, Newark, DE, United States;1. School of Mechanical & Materials Engineering, University College Dublin, Belfield, Dublin, Ireland;2. School of Mechanical & Manufacturing Engineering, Dublin City University, Glasnevin, Dublin, Ireland |
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| Abstract: | The mechanical properties of brain tissue in vivo determine the response of the brain to rapid skull acceleration. These properties are thus of great interest to the developers of mathematical models of traumatic brain injury (TBI) or neurosurgical simulations. Animal models provide valuable insight that can improve TBI modeling. In this study we compare estimates of mechanical properties of the Yucatan mini-pig brain in vivo and ex vivo using magnetic resonance elastography (MRE) at multiple frequencies. MRE allows estimations of properties in soft tissue, either in vivo or ex vivo, by imaging harmonic shear wave propagation. Most direct measurements of brain mechanical properties have been performed using samples of brain tissue ex vivo. It has been observed that direct estimates of brain mechanical properties depend on the frequency and amplitude of loading, as well as the time post-mortem and condition of the sample. Using MRE in the same animals at overlapping frequencies, we observe that porcine brain tissue in vivo appears stiffer than porcine brain tissue samples ex vivo at frequencies of 100 Hz and 125 Hz, but measurements show closer agreement at lower frequencies. |
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| Keywords: | Magnetic resonance elastography Brain tissue stiffness Shear modulus Post-mortem tissue changes Porcine brain |
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