Estimation of in vivo inter-vertebral loading during motion using fluoroscopic and magnetic resonance image informed finite element models |
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| Institution: | 1. School of Physics and Astronomy, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK;2. Institute for Musculoskeletal Research and Clinical Implementation, Anglo-European College of Chiropractic, Bournemouth, UK;3. Faculty of Science and Technology, Bournemouth University, Bournemouth, UK;1. Biomedical Engineering Institute, Bo?aziçi University, Istanbul, Turkey;2. Mayo Clinic, Rochester, USA;1. Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands;2. Department of Orthopedic Surgery, State University of New York, Upstate Medical University, Syracuse, NY, USA;3. University of Twente, Laboratory for Biomechanical Engineering, Faculty of Engineering Technology, Enschede, The Netherlands;1. Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA;2. PERCRO Laboratory, TeCIP Institute, Scuola Superiore Sant’Anna, via Alamanni 13b, 56010 Ghezzano, San Giuliano Terme, Pisa, Italy;3. Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA;1. School of Engineering and Applied Science, University of Virginia, Charlottesville, VA 22904, USA;2. Department of Mechanical Engineering, Dublin City University, Glasnevin, Dublin 9, Ireland;1. Center for Health & Bioresources, AIT Austrian Institute of Technology, Vienna, Austria;2. Institute for Analysis and Scientific Computing, Vienna University of Technology, Vienna, Austria |
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| Abstract: | Finite element (FE) models driven by medical image data can be used to estimate subject-specific spinal biomechanics. This study aimed to combine magnetic resonance (MR) imaging and quantitative fluoroscopy (QF) in subject-specific FE models of upright standing, flexion and extension. Supine MR images of the lumbar spine were acquired from healthy participants using a 0.5 T MR scanner. Nine 3D quasi-static linear FE models of L3 to L5 were created with an elastic nucleus and orthotropic annulus. QF data was acquired from the same participants who performed trunk flexion to 60° and trunk extension to 20°. The displacements and rotations of the vertebrae were calculated and applied to the FE model. Stresses were averaged across the nucleus region and transformed to the disc co-ordinate system (S1 = mediolateral, S2 = anteroposterior, S3 = axial). In upright standing S3 was predicted to be ?0.7 ± 0.6 MPa (L3L4) and ?0.6 ± 0.5 MPa (L4L5). S3 increased to ?2.0 ± 1.3 MPa (L3L4) and ?1.2 ± 0.6 MPa (L4L5) in full flexion and to ?1.1 ± 0.8 MPa (L3L4) and ?0.7 ± 0.5 MPa (L4L5) in full extension. S1 and S2 followed similar patterns; shear was small apart from S23. Disc stresses correlated to disc orientation and wedging. The results demonstrate that MR and QF data can be combined in a participant-specific FE model to investigate spinal biomechanics in vivo and that predicted stresses are within ranges reported in the literature. |
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| Keywords: | Finite element model Lumbar spine Fluoroscopy Magnetic resonance imaging |
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