| 儿童结核病耐药状况及危险因素分析 |
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| 引用本文： | 彭哲,刘芮汐,李奇志,幸琳琳,朱朝敏.儿童结核病耐药状况及危险因素分析[J].中国微生态学杂志,2011,23(7):644-646. |
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| 作者姓名： | 彭哲 刘芮汐 李奇志 幸琳琳 朱朝敏 |
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| 作者单位： | 重庆医科大学附属儿童医院,感染消化科;儿童发育疾病研究省部共建教育部重点实验室,儿科学重庆市重点实验室,重庆市(儿童发育重大疾病诊疗与预防)国际科技合作基地,重庆,400014 |
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| 基金项目： | 重庆市卫生局科研基金(2008-2-177) |
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| 摘 要： | 目的了解最新儿童耐药结核病流行现状,为耐药儿童结核病的预防、控制提供依据。方法于2006年6月至2009年6月间收集了重庆医科大学附属儿童医院161例结核病患儿样本,采用比例法对链霉素(Streptomycin,SM)、异烟肼(Isoniazide,INH)、利福平(Rifampicin,RFP)、乙胺丁醇(Ethambutol,EMB)和吡嗪酰胺(Pyrazinamide,PZA)共5种药物进行耐药性测定。结果 161株菌株中鉴定出139例为结核分枝杆菌,对这139例培养阳性儿童结核病例中,总耐药率和总耐多药率分别为20.86%、6.47%,平均耐药率顺位由高到低是SM(12.2%)、INH(10.79%)、RFP(8.63%)、EMB(2.88%)、PZA(2.88%)。结论重庆地区儿童结核病总体耐药及耐多药水平低于全国平均水平,城镇地区及复治患儿可能是儿童结核病病例发生多耐药的相关因素。
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| 关 键 词： | 耐药 儿童 结核病 |
Risk factors of drug-resistant pediatric tuberculosis patients |
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| PENG Zhe,LIU Rui-xi,LI Qi-zhi,XING Lin-lin,ZHU Chao-min.Risk factors of drug-resistant pediatric tuberculosis patients[J].Chinese Journal of Microecology,2011,23(7):644-646. |
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| Authors: | PENG Zhe LIU Rui-xi LI Qi-zhi XING Lin-lin ZHU Chao-min |
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| Institution: | PENG Zhe,LIU Rui-xi,LI Qi-zhi,XING Lin-lin,ZHU Chao-min (Division of Infectious Disease and Gastroenterology,Children's Hospital,Chongqing Medical University,Key Laboratory of Pediatrics in Chongqing,CSTC2009CA5002,Chongqing International Science and Technology Cooperation Center for Child Development and Disorders,Chongqing 400014,China) |
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| Abstract: | Objective To explore the latest prevalence of drug-resistant pediatric tuberculosis and find basis for prevention,control and treatment of drug-resistant tuberculosis.Method Cases diagnosed as pediatric tuberculosis were collected from Children's Hospital of Chongqing Medical University,Chongqing from June 2006 to June 2009.Proportion method was used to test the drug susceptibility to streptomycin(SM),isoniazide(INH),rifampicin(RFP),ethambutol(EMB) and pyrazinamide(PZA).Result 139 cases were identified as M... |
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| Keywords: | Drug resistance Children Tuberculosis |
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