| C57BL/6J慢性应激小鼠血中胆固醇和甘油三酯的变化 |
| |
| 引用本文： | 赵心宇,赵宝霞,綦霞,孟秀香,刘纯青. C57BL/6J慢性应激小鼠血中胆固醇和甘油三酯的变化[J]. 中国微生态学杂志, 2011, 23(6): 527-528,532 |
| |
| 作者姓名： | 赵心宇 赵宝霞 綦霞 孟秀香 刘纯青 |
| |
| 作者单位： | 大连医科大学,检验医学院,辽宁,大连,116044 |
| |
| 摘 要： | 目的观察慢性应激对C57BL/6J小鼠行为和血液中血脂的影响。方法将20~25 g雄性C57BL/6J小鼠分成应激组及相应的对照组。应激组小鼠独笼饲养,将6个日相和6个夜相刺激及1个全天刺激随机安排到1周内,每周刺激顺序随机重新组合,连续8周。对照组动物则每5~6只小鼠合笼饲养,自由给水,整个实验过程中不接受任何刺激。2组动物均于刺激后的1、2、4和8周经内眦取血,用于血脂的检测。结果行为学实验结果显示:除第8周外,刺激后各时间点模型组小鼠体重均明显低于对照组(P<0.05)。空腹胆固醇及甘油三酯检查结果显示:与对照组相比较,模型组小鼠自刺激后的第2、4、8周显著增加(P<0.01),相反甘油三酯则在个时间点均显著降低(P<0.05)。结论复合式慢性应激是一种建立应激动物模型的有效方式;应激形成过程中动物体内胆固醇的增加提示长期的应激很可能对心血管系统造成一定危害。
|
| 关 键 词： | 慢性复合式应激 血脂 C57BL小鼠 |
The changes of cholesterol and triglyceride in the blood of chronic stress C57BL/6J mice |
| |
| ZHAO Xin-yu,ZHAO Bao-xia,QI Xia,MENG Xiu-xiang,LIU Chun-qing. The changes of cholesterol and triglyceride in the blood of chronic stress C57BL/6J mice[J]. Chinese Journal of Microecology, 2011, 23(6): 527-528,532 |
| |
| Authors: | ZHAO Xin-yu ZHAO Bao-xia QI Xia MENG Xiu-xiang LIU Chun-qing |
| |
| Affiliation: | ZHAO Xin-yu,ZHAO Bao-xia,QI Xia,MENG Xiu-xiang,LIU Chun-qing(Department of Laboratory Diagnostic Medicine,Dalian Medical University,Dalian 116044,China) |
| |
| Abstract: | Objective To study the the effect of chronic compound stress on hematopoietic system in C57BL/6J mice.Method C57BL/6J mice weighing at 20 to 25 g were randomly divided into stress group and control group.The mice in the stress group were housed alone.Six day-stimulations,6 night-stimulations and 1 full-day-stimulation were randomly arranged into one week.The week-stumulation lasted 8 successive weeks and all the stimulations were randomly re-arranged in each week.The mice in the control group were housed to... |
| |
| Keywords: | Chronic compound stress Blood-lipid C57BL mice |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
