| 单增李斯特菌生物膜及其形成机制的研究进展 |
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| 引用本文： | 柯春林,方维焕. 单增李斯特菌生物膜及其形成机制的研究进展[J]. 中国微生态学杂志, 2011, 23(6): 574-577 |
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| 作者姓名： | 柯春林 方维焕 |
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| 作者单位： | 1. 蚌埠学院,生物与食品工程系,安徽,蚌埠,233030
2. 浙江大学,动物预防医学研究所,浙江,杭州,310029 |
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| 基金项目： | 蚌埠学院博士科研启动基金项目,蚌埠学院优秀人才基金项目 |
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| 摘 要： | 单增李斯特菌(Lm)是重要的人兽共患食源性病原菌。Lm生物膜与其致病性和耐药性密切相关。影响Lm生物膜形成的关键因子有鞭毛糖蛋白、胞外基质和群体感应系统等。鞭毛糖蛋白能促进菌体聚集,从而直接影响生物膜的形成。胞外DNA参与Lm粘附和生物膜早期的形成,并与胞外多糖和胞外结合蛋白一起构成生物膜胞外基质。Lm的Agr群体感应系统正调控生物膜形成,是一种集合毒力因子、耐药因子和生物膜的整体水平调控网络体系。
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| 关 键 词： | 单增李斯特菌 生物膜 胞外基质 群体感应 形成机制 |
Research on the biofilm and its mechanism of Listeria monocytogenes |
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| KE Chun-lin,FANG Wei-huan. Research on the biofilm and its mechanism of Listeria monocytogenes[J]. Chinese Journal of Microecology, 2011, 23(6): 574-577 |
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| Authors: | KE Chun-lin FANG Wei-huan |
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| Affiliation: | KE Chun-lin1,FANG Wei-huan2 (1.Department of Biotechnology and Food Engineering,Bengbu College,Bengbu 233030,China,2.Institute of Preventive Veterinary Medicine,Zhejiang University,Hangzhou 310029,China) |
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| Abstract: | Listeria monocytogenes is a Gram-positive pathogen involved in numerous foodborne disease outbreaks.The biofilm of Listeria monocytogenes is closely related to its pathogenicity and drug resistance.The key factors that have effects on biofilm formation are flagella glycoprotein,extracellular matrix and quorum sensing.Biofilm formation by Listeria monocytogenes is dependent on flagellar motility to propel the cells towards a surface prior to attachment.The biofilm matrix of Listeria monocytogenes contains ex... |
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| Keywords: | Listeria monocytogenes Biofilm Extracellular matrix Quorum sensing Mechanism |
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