Aqueous, oil, and ointment formulations of ketorolac: efficacy against prostaglandin E2-induced ocular inflammation and safety: A technical note |
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| Authors: | Manjusha Malhotra Dipak K Majumdar |
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| Institution: | (1) Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, 125 001 Haryana, India;(2) L.B.Rao Institute of Pharmaceutical Education and Research, Khambat, Anand, Gujarat, 388 620, India;(3) Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, (University of Delhi), Pushp Vihar, Sector III, New Delhi, 110017, India; |
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| Abstract: | The efficacy of aqueous, oil, and ointment formulations of ketorolac against PGE2-induced ocular inflammation in rabbits was evaluated, with monitoring of blinking rate and PMN and protein migration in tear
fluid, following topical PGE2 instillation. Ketorolac ophthalmic formulations protected the eye against inflammatory insult. Chronic topical administration
of formulations for 10 days into rats' eyes did not lead to any appreciable gastrointestinal ulceration, which indicates that
the formulations are safe for long-term use. |
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