小鼠睾丸表皮生长因子受体及增殖细胞核抗原表达的加龄变化研究

观察了表皮生长因子受体及增殖细胞核抗原在生后１天至生后１０月龄昆明种小鼠睾丸内的表达，结果表明：精原细胞及初级精线产细胞从生后第２周至生后４周龄ＤＮＡ复制旺盛，增殖细胞核抗原免疫反应阳性细胞面密度于生后１４天出现峰值。生长因子受体在间质细胞、精母细胞内均有表达。生后４周时，精母细胞表皮生长因子受体表达较强，便于表皮生长因子发挥调节细胞增殖、调亡的作用。

Study on the Age-Specific Changes of EGFR and PCNA in the Seminiferous Epithelium of the Mouse

The express of EGFR and PCNA in the seminiferous epithelium was observed during a series of developing stages from birth to postnatal 10th month with SP method. The results show that: between 2nd and 4th weeks after birth replicating activity of DNA in spermatogonia and primary spermatocytes were flourishing. Surface densities of PCNA|positive cells reached up their peaks on 14th day after birth through measurements of IP|8 computer image analysis system. There were expression of EGFR in Leydig cells and spermatocytes, and the stronger expression of EGFR was located at spermatocytes during postnatal fourth week.