Bacterial adhesins: structural studies reveal chaperone function and pilus biogenesis |
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Authors: | Knight S D Berglund J Choudhury D |
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Institution: | Swedish University of Agricultural Sciences, Uppsala Biomedical Center, Department of Molecular Biology, PO Box 590, SE 751 24, Uppsala, Sweden. stefan@xray.bmc.uu.se |
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Abstract: | During the past year, remarkable progress has been made in understanding how periplasmic chaperones fold and protect protein modules that are destined for assembly into adhesive pili in Gram-negative bacteria. The first two three-dimensional structures of complexes of periplasmic chaperones with substrate pilus subunits have revealed much about the structural basis for chaperone-mediated folding and aggregation prevention, and have provided insight into the structure of adhesive pili. |
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Keywords: | Adhesins pilus biogenesis chaperone usher donor strand complementation protein folding |
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