A new antimicrobial peptide isolated from Oudneya africana seeds |
| |
| Authors: | Riadh Hammami Jeannette Ben Hamida Gérard Vergoten Jean‐Marie Lacroix Marie‐Christine Slomianny Neffati Mohamed Ismail Fliss |
| |
| Institution: | 1. Unity of Functional Proteomics and Food Biopreservation, Higher Institute of Applied Biological Sciences of Tunis, University Tunis El Manar, Tunis, Tunisia;2. UMR CNRS 8576, Department of Structural and Functional Glycobiology, University of Sciences and Technology of Lille, Lille, France;3. Institute of Nutrition and Functional Food (INAF), Laval University, Quebec, Canada;4. Laboratory of Pastoral Ecology, National institute of the Arid Areas, Médenine, Tunisia |
| |
| Abstract: | Oudneya africana R. Br. (Brassicaceae), a wild‐growing plant in the arid region of Tunisia, is used in ethno‐medicinal treatment of microbial infections. Validation of ethno‐therapeutic claims pertaining to the plant was sought by investigating its antimicrobial activity. A proteinaceous extract of the seeds, called AS‐3000, showed activity against various organisms including L. monocytogenes, E. coli, B. subtilis, E. hirae, P. aeruginosa, S. aureus and C. albicans. Extract AS‐3000 exhibited a synergistic effect against L. ivanovii when combined with vancomycin or chloramphenicol. The post‐antibiotic inhibitory effect of the ampicillin/AS‐3000 combination was 2.3‐fold greater than for the antibiotic alone. The mode of action of AS‐3000 on Listeria and Escherichia was visible using SEM. These results support the use of O. africana for treating microbial infections. |
| |
| Keywords: | antimicrobial peptide Oudneya africana plant extract synergism |
|
|
