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Structural bioinformatics mutation analysis reveals genotype–phenotype correlations in von Hippel‐Lindau disease and suggests molecular mechanisms of tumorigenesis
Authors:Julia R. Forman  Catherine L. Worth  G. Richard J. Bickerton  Tim G. Eisen  Tom L. Blundell
Affiliation:1. Biocomputing Group, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom;2. Current address: Institut Pasteur, Unité de Bioinformatique Structurale, 25‐28 rue du Docteur Roux, 75015 Paris, France;3. Current address: Structural Bioinformatics Group, Leibniz‐Institut für Molekulare Pharmakologie (FMP), Campus Berlin‐Buch, Robert‐Roessle‐Str. 10, 13125 Berlin, Germany;4. Current address: Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom;5. Department of Oncology, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom
Abstract:
Keywords:bioinformatics  biocomputing  mutation  cancer  genotype–  phenotype  VHL
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