Oxidant Stress in Healthy Normal‐weight,Overweight, and Obese Individuals |
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| Authors: | Louise A. Brown Catherine J. Kerr Paul Whiting Nicholas Finer Jane McEneny Tony Ashton |
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| Affiliation: | 1. School of Physical Education and Sport Sciences, University of Bedfordshire, Bedford, UK;2. Centre for Obesity Research, Luton and Dunstable Hospital NHS Trust, Luton, UK;3. Faculty of Health and Life Sciences, Hawthorn Building, Leicester, UK;4. Wellcome Clinical Research Facility, Addenbrooke's Hospital, Cambridge, UK;5. Department of Medicine, Nutrition and Metabolism Group, The Queen's University of Belfast, Centre for Clinical and Population Sciences, Belfast, UK |
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| Abstract: | This study was undertaken to investigate the association among BMI and lipid hydroperoxide (LH), total antioxidant status (TAS), superoxide dismutase (SOD), and reduced glutathione (GSH). Ninety (n = 90) healthy males and females (n = 23/67) (29 normal weight (BMI: 22.74 ± 0.25 kg/m2), 36 overweight (BMI: 27.18 ± 0.23 kg/m2), and 25 obese (33.78 ± 0.48 kg/m2)) participated in the study. Data collected included anthropometric measures, fasting blood glucose, lipid profile, LH, TAS, and enzymatic antioxidants (SOD, and reduced GSH). The results of the study showed that obese individuals had significantly increased LH levels compared to normal‐weight individuals (obese vs. normal weight (0.88 ± 0.05 vs. 0.67 ± 0.03 µmol/l, P < 0.01)) but the increased levels were not significantly different when compared to the overweight group (obese vs. overweight (0.88 ± 0.05 vs. 0.79 ± 0.05 µmol/l)). No other consistent significant differences in TAS, SOD, and GSH were identified between groups. This study concluded that only obesity and not moderate overweight elevates LH levels. Furthermore, the levels of TAS, SOD, and GSH in obesity do not explain the increased LH levels observed in obesity. |
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