Antibody recognition of cell surface-associated NS1 triggers Fc-gamma receptor-mediated phagocytosis and clearance of West Nile Virus-infected cells |
| |
Authors: | Chung Kyung Min Thompson Bruce S Fremont Daved H Diamond Michael S |
| |
Affiliation: | Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. |
| |
Abstract: | Previous studies have suggested that monoclonal antibodies (MAbs) to flavivirus nonstructural protein-1 (NS-1) protect against infection in mice through an Fc-gamma receptor-dependent pathway. To identify a specific mechanism, we evaluated the protective activity of anti-NS1 MAbs to WNV using mice and cells with deficiencies of specific Fc-gamma receptors. Our results suggest that only MAbs that recognize cell surface-associated NS1 trigger Fc-gamma receptor I- and/or IV-mediated phagocytosis and clearance of WNV-infected cells. These findings may be relevant for generating novel therapeutic MAbs or vaccines against flaviviruses that target the NS1 protein. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|