Study of the RESS Process for Producing Beclomethasone-17,21-Dipropionate Particles Suitable for Pulmonary Delivery |
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Authors: | Paul A Charpentier Ming Jia Rahima A Lucky |
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Institution: | (1) Department of Chemical and Biochemical Engineering, University of Western Ontario, N6A 5B9 London, Ontario, Canada |
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Abstract: | The purpose of this research was to micronize beclomethasone-17,21-dipropionate (BDP), an anti-inflammatory inhaled corticosteroid
commonly used to treat asthma, using the rapid expansion of supercritical solution (RESS) technique. The RESS technique was
chosen for its ability to produce both micron particles of high purity for inhalation, and submicron/nano particles as a powder
handling aid for use in next generation dry powder inhalers (DPIs). Particle formation experiments were carried out with a
capillary RESS system to determine the effect of experimental conditions on the particle size distribution (PSD). The results
indicated that the RESS process conditions strongly influenced the particle size and morphology; with the BDP mean particle
size decreasing to sub-micron and nanometer dimensions. An increase in the following parameters, i.e. nozzle diameter, BDP
mol fraction, system pressure, and system temperature; led to larger particle sizes. Aerodynamic diameters were estimated
from the SEM data using three separate relations, which showed that the RESS technique is promising to produce particles suitable
for pulmonary delivery. |
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Keywords: | asthma beclomethasone dipropionate crystallization micronization supercritical fluid processing |
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