| Abstract: | Methomyl was 15 and 31.3 times more toxic than bendiocarb to bulb mites at the LC50 and LC90 values respectively. However, methomyl (pI50 3.0) was at least 126 times less active than bendiocarb (pI50 5.1) as an inhibitor of bulb mite cholinesterase in vitro. The disparity between the high toxicity of methomyl and its extremely low activity as an inhibitor of mite cholinesterase in vitro indicated that another mechanism was likely involved in its toxic action. Pharmacokinetic studies of methomyl and bendiocarb showed that penetration and metabolism were rapid and that there were no substantial differences in the internal levels of the respective parent carbamates during the 24 h test period. However, volatile radioactive material(s), some of which was carbon dioxide, was produced in appreciably greater amounts from methomyl than from bendiocarb. We speculate that the production of volatiles, such as carbon dioxide, acetonitrile and/or methylamine, may contribute to the toxicity of methomyl to bulb mites. © Rapid Science Ltd. 1998 |
