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Sequence context affects the rate of short insertions and deletions in flies and primates
Authors:Amos Tanay  Eric D Siggia
Institution:(1) Center for Studies in Physics and Biology, The Rockefeller University, York Ave, New York, NY 10021, USA;(2) Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, 76100, Israel
Abstract:

Background  

Insertions and deletions (indels) are an important evolutionary force, making the evolutionary process more efficient and flexible by copying and removing genomic fragments of various lengths instead of rediscovering them by point mutations. As a mutational process, indels are known to be more active in specific sequences (like micro-satellites) but not much is known about the more general and mechanistic effect of sequence context on the insertion and deletion susceptibility of genomic loci.
Keywords:
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