Inducers of immunogenic cancer cell death |
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| Authors: | Aleksandra M. Dudek Abhishek D. Garg Dmitri V. Krysko Dirk De Ruysscher Patrizia Agostinis |
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| Affiliation: | 1. Cell Death Research & Therapy Unit, Department of Cellular and Molecular Medicine, University of Leuven (KU Leuven), Leuven, Belgium;2. Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium;3. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium;4. Radiation Oncology, University Hospitals Leuven/KU Leuven, Department of Oncology, Leuven, Belgium |
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| Abstract: | Recently, cytokine-based pro-tumourigenic signalling has been found to play a major role in the immune system's pro-tumourigenic activity. On the other hand, other recent findings have shown that immunogenic cancer cell death triggered by certain anticancer modalities might reset the dysfunctional immune system towards the activation of a long-lasting protective anti-tumour response. Therefore, using inducers of immunogenic cell death (ICD) that can prevent or impede tumour-promoting cytokine signalling is one of the best ways of instigating or restoring efficient anti-tumour immunity. In this review it is discussed, how the different ICD inducers interact with the immune system and influence cytokine-based pro-tumourigenic signalling. We believe that it is crucial to discover or develop new anti-cancer therapeutic modalities that can induce ICD and impede tumour-promoting cytokine signalling. |
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