Removal of residual methylene chloride from homoharringtonine by pre-treatment with ethanol |
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Authors: | Ji-Yeon Lee Jin-Hyun Kim |
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Institution: | Department of Chemical Engineering, Kongju National University, Cheonan 330-717, South Korea |
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Abstract: | In this study, methylene chloride, which is a residual solvent in final purified homoharringtonine, was removed effectively through pre-treatment with ethanol. When the final HPLC-purified sample was concentrated using a rotary evaporator, the residual methanol easily met the ICH-specified value (3000 ppm), but methylene chloride did not meet the ICH-specified value (600 ppm). However, when the sample (methylene chloride: 10,000 ppm, methanol: 500 ppm) was concentrated through pre-treatment with 95% ethanol using a rotary evaporator, the residual methylene chloride easily met the ICH-specified value. Also, the residual ethanol (concentration > 10,000 ppm) was removed effectively below the ICH-specified value (5000 ppm) through microwave-assisted drying (microwave power: 400 W). |
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Keywords: | Homoharringtonine Residual methylene chloride Removal Pre-treatment Ethanol |
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