A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system |
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Authors: | Iain Comerford Yuka Harata-Lee Mark D Bunting Carly Gregor Ervin E Kara Shaun R McColl |
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Institution: | The Chemokine Biology Laboratory, School of Molecular and Biomedical Science, University of Adelaide, Australia |
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Abstract: | The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of T cells and DCs to T cell areas of lymphoid tissues where T cell priming occurs. However, CCR7 and its ligands also contribute to a multitude of adaptive immune functions including thymocyte development, secondary lymphoid organogenesis, high affinity antibody responses, regulatory and memory T cell function, and lymphocyte egress from tissues. In this survey, we summarise the role of CCR7 in adaptive immunity and describe recent progress in understanding how this axis is regulated. In particular we highlight CCX-CKR, which scavenges both CCR7 ligands, and discuss its emerging significance in the immune system. |
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Keywords: | Chemokine CCR7 CCL19 CCL21 Immunity |
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