Interleukin-1 augments the interleukin-2-dependent generation of natural killer cells from bone marrow precursors |
| |
| Authors: | G Migliorati L Cannarile L D'Adamio R B Herberman C Riccardi |
| |
| Institution: | Institute of Pharmacology, School of Medicine, University of Perugia, Italy. |
| |
| Abstract: | We have studied the possible role of interleukin-1 (IL-1) on the interleukin-2 (IL-2) dependent development of mouse natural killer (NK) cells from primitive bone marrow (BM) precursors. Results indicate that both IL-1 alpha and IL-1 beta (1-10 U/ml) are able to stimulate the generation of NK cells from 5-fluorouracil (5-FU) resistant BM progenitors. These precursor cells are asialoGM1-, Thy-1+, Lyt-1- and Lyt-2-. Effector cells generated by culturing with IL-2 (40 U/ml) and IL-1 (5 U/ml) are Thy-1+, asialoGM1+, Lyt-5+, Lyt-1-, Lyt-2- and lyse only NK-susceptible targets. Generation of NK cells is blocked by addition of anti-IL-2/r. These data indicate that IL-1 may play a role in the generation of mature NK cells from undifferentiated BM precursors. |
| |
| Keywords: | |
|
|
