Conversion of guanosine 3', 5'-monophosphate to adenosine 3', 5'-monophosphate in frog myocardial tissue. |
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Authors: | M Simon |
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Institution: | Laboratoire d''Enzymologie Microbienne C.N.R.S. 91190 - Gif sur Yvette, France |
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Abstract: | One of the transformation products of tritiated cyclic GMP in frog heart tissue homogenate was identified with cyclic AMP. The purified product met all criteria tested for: solubility in ZnCO3, behavior on various ion-exchangers and sensitivity to cyclic nucleotide phosphodiesterase. Our findings may provide insight into the understanding of heart pacemaker activity. |
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