Prevalence of antibodies to selected viruses in a long-term closed breeding colony of rhesus macaques (Macaca mulatta) in Brazil |
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Authors: | Andrade Marcia Ribeiro Yee Joann Barry Peter Spinner Abigail Roberts Jeffrey A Cabello Pedro H Leite Jose Paulo Lerche Nicholas W |
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Affiliation: | Oswaldo Cruz Foundation, Centro de Cria??o de Animais de Loboratório, Rio de Janeiro, Brazil. andrade@cecal.fiocruz.br |
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Abstract: | The rhesus macaque breeding colony of the Oswaldo Cruz Foundation (FIOCRUZ) was established in 1932 from a founding stock of 100 animals. This population has remained closed to new animal introductions for almost 70 years. A serologic survey was performed to determine the prevalence of antibodies to selected viruses as a first approach to identifying viral pathogens endemic in this population. Banked serum samples were tested for antibodies to simian immunodeficiency virus (SIV), simian T-lymphotropic virus (STLV), simian type D retrovirus (SRV), cercopithecine herpesvirus type-1 (B virus), rhesus cytomegalovirus (RhCMV), measles virus (MV), and hepatitis A virus (HAV). All samples were negative for antibodies against the simian retroviruses. The overall prevalence of antibodies was 95% for RhCMV, 45% for B virus, 35% for HAV, and 1% for MV. Prevalence was found to vary by age group. |
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Keywords: | nonhuman primates serology serological survey health monitoring viruses |
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