Two human genes encoding zinc finger proteins,ZNF12 (KOX 3) and ZNF 26 (KOX 20), map to chromosomes 7p22-p21 and 12q24.33, respectively |
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| Authors: | P Seite K Huebner M F Rousseau-Merck R Berger H J Thiesen |
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| Institution: | (1) INSERM U.301 et S.D.I No. 15954 I CNRS, Institut de Génétique Moléculaire, 27, Rue Juliette Dodu, F-75010 Paris, France;(2) Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 19140 Philadelphia, PA, USA;(3) Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005 Basel, Switzerland;(4) U. 301 INSERM, Institut de Génétique Moléculaire, 27, Rue Juliette Dodu, F-75010 Paris, France |
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| Abstract: | Summary Two members of the human zinc finger Krüppel family, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), have been localized by somatic cell hybrid analysis and in situ chromosomal hybridization. The presence of individual human zinc finger genes in mouse-human hybrid DNAs was correlated with the presence of specific human chromosomes or regions of chromosomes in the corresponding cell hybrids. Analysis of such mouse-human hybrid DNAs allowed the assignment of the ZNF 12 (KOX 3) gene to chromosome region 7p. The ZNF 26 (KOX 20) gene segregated with chromosome region 12q13-qter. The zinc finger genes ZNF 12 (KOX 3) and ZNF 26 (KOX 20) were localized by in situ chromosomal hybridization to human chromosome regions 7p22-21 and 12q24.33, respectively. These genes and the previously mapped ZNF 24 (KOX 17) and ZNF 29 (KOX 26) genes, are found near fragile sites. |
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