P53 and Beta-Catenin Activity during Estrogen treatment of Osteoblasts期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

P53 and Beta-Catenin Activity during Estrogen treatment of Osteoblasts

Authors:	Nalini?Chandar author-information" > author-information__contact u-icon-before" > mailto:nchand@midwestern.edu" title=" nchand@midwestern.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Rasleen?Saluja,Peter?C?Lamar,Kevin?Kolman,Walter?C?Prozialeck

Affiliation:	(1) Department of Biochemistry, Chicago College of Osteopathic Medicine, Midwestern University, 555, 31st Street, Downers Grove, IL 60515, USA;(2) Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555, 31st Street, Downers Grove, IL 60515, USA

Abstract:	Background This study was undertaken to examine the relationship between the tumor suppressor gene p53 and the nuclear signaling protein beta-catenin during bone differentiation. Cross talk between p53 and beta-catenin pathways has been demonstrated and is important during tumorigenesis and DNA damage, where deregulation of beta catenin activates p53. In this study, we used estrogen treatment of osteoblasts as a paradigm to study the relationship between the two proteins during osteoblast differentiation.

Keywords:
本文献已被 SpringerLink 等数据库收录！