Neuritogenic determinant of bovine P2 protein in peripheral nerve myelin期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Neuritogenic determinant of bovine P2 protein in peripheral nerve myelin

Authors:	K Uyemura M Suzuki K Kitamura K Horie Y Ogawa H Matsuyama S Nozaki I Muramatsu

Affiliation:	Department of Physiology, Saitama Medical School, Saitama, Japan;Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan;Department of Microbiology, Faculty of Pharmaceutical Science, Josai University, Saitama, Japan;Department of Chemistry, College of Science, Rikkyo University, Tokyo, Japan

Abstract:	Abstract: Experimental allergic neuritis (EAN) is an experimentally produced demyelinating disease of peripheral nervous system. Several peptides of bovine P₂ protein were tested for neuritogenic activity in Lewis rats. The hexacosapeptide CiT4 (residues 53-78 of bovine P₂ protein) showed the highest neuritogenic activity among the peptides tested. The nonapeptide (residues 70-78) and the tridecapeptide (residues 66-78) were synthesized using the liquid phase peptide synthesis technique. The tridecapeptide showed mild, but definite activity in inducing EAN in the rats, while the nonapeptide was inactive. The localization of the neuritogenic determinant of bovine P₂ protein in Lewis rats is discussed.

Keywords:	Peripheral nerve Myelin P₂ protein Peptide Experimental allergic neuritis Demyelination
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