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Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon |
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| Authors: | Brendan S Crabb Tania F de Koning-Ward Paul R Gilson |
| Affiliation: | (1) Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, 3004, Australia;(2) The University of Melbourne, Melbourne, Victoria, 3004, Australia;(3) Monash University, Clayton, Victoria, 3800, Australia;(4) Deakin University, Waurn Ponds, Victoria, 3217, Australia |
| Abstract: | The ability to analyze gene function in malaria-causing Plasmodium parasites has received a boost with a recent paper in BMC Genomics that describes a genome-wide mutagenesis system in the rodent malaria species Plasmodium berghei using the transposon piggyBac. This advance holds promise for identifying and validating new targets for intervention against malaria. But further improvements are still needed for the full power of genome-wide molecular genetic screens to be utilized in this organism. |
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