Centric fission of chromosome No. 4 in the mother of two patients with trisomy 4p |
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| Authors: | Bruno Dallapiccola Pierpaolo Mastroiacovo Enrico Gandini |
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| Institution: | (1) Cattedra di Genetica Medica, Università di Roma, Italy;(2) Clinica Pediatrica, Università Cattolica di Roma, Roma, Italy |
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| Abstract: | Summary Centric fission of chromosome No. 4 was found in the healthy mother of two children with trisomy 4p. The two telocentrics derived are stable and show no evidence of fusing again. the 2:3 ratio of unbalanced offsprings born to the proposita indicates that, contrary to the evidence emerging from studies in other species, the risk for the production of unbalanced gametes is high. |
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