Lipogenesis from U14C lactate in obese Zucker rat hepatocytes. Effect of albumin-bound oleate |
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| Authors: | D Porquet N Serbource-Goguel G Durand J Maccario J Féger J Agneray |
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| Institution: | 1. Department of Biochemistry, U.E.R. des Sciences Pharmaceutiques et Biologiques, Université Paris-Sud, France;7. Department of Mathematics, U.E.R. des Sciences Pharmaceutiques et Biologiques, Université Paris-Sud, France |
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| Abstract: | Lipogenesis from U(14C) lactate was studied in hepatocytes isolated from obese Zucker rats (fa/fa) their lean littermates (Fa/?) and Sprague Dawley rats. The distribution of radioactive carbon between the glycerol and the fatty acid moieties of the acylglycerols were studied. Radioactive lactate was better utilized for glycerol formation than it was for fatty acid formation in the obese rats. However, when oleate was added to the hepatocytic incubation medium, radioactive lactate was preferentially incorporated into the fatty acid moiety of the acylglycerols. |
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