Peculiarities of Development of the Depression State in Rats Characterized by Different Individual/Typological Behavioral Statuses

We examined the development of a depression state induced by long-lasting stressing of rats preliminarily selected according to their active or passive behavior pattern. Stress was induced using a technique of sensory contact with aggressive individuals. The pathologically modified state in animals of the above groups developed according to dissimilar scenarios. As a result, a depressive state similar to anxious depression developed in active animals, while psychoemotional disorders similar to a melancholy-type depression were formed in passive rats. Therefore, the symptomatic heterogeneity of depression is, to a considerable extent, determined by individual/typological peculiarities of behavior (passive vs active) and can be rather clearly identified using the sensory contact technique.