N-alkyl-5H-pyrido[4,3-b]indol-1-amines and derivatives as novel urotensin-II receptor antagonists |
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| Authors: | Wang Yonghui Wu Zining Guida Brian F Lawrence Sarah K Neeb Michael J Rivero Ralph A Douglas Stephen A Jin Jian |
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| Affiliation: | Oncology CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA. yonghui.2.wang@gsk.com |
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| Abstract: | High throughput screening of our compound collection led to the discovery of a novel series of N-alkyl-5H-pyrido[4,3-b]indol-1-amines as urotensin-II receptor antagonists. Synthesis, initial structure and activity relationships, functional and animal ortholog activities of the series are described. |
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