Rubella in teenagers: epidemiology and prophylaxis in Siena, Italy |
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| Authors: | C Cellesi M L Bandinelli M G Cusi M L Di Cairano P E Valensin A Barberi A Rossolini |
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| Affiliation: | 2. Institute of Infectious Diseases, University of Siena, via P.A. Mattioli 10, 53100 Siena, Italy;3. Institute of Microbiology, University of Siena, via Laterina 8, 53100 Siena, Italy;1. Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, United States;2. Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, United States;3. TB Modelling Group, Centre for Mathematical Modelling of Infectious Diseases, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom;4. Public Health England, London, United Kingdom;5. Programme National de Lutte Contre les IST/SIDA, Ministry of Public Health, Kinshasa, The Democratic Republic of the Congo;6. Expanded Programme on Immunization, Ministry of Public Health, Kinshasa, The Democratic Republic of the Congo;7. Division of Global HIV/AIDS, Centers for Disease Control and Prevention, Kinshasa, The Democratic Republic of the Congo;1. Global Immunization Division, US Centers for Disease Control and Prevention, Atlanta, United States;2. Solomon Islands Ministry of Health and Medical Services, Honiara, Solomon Islands;3. Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, United States;4. World Health Organization Office of the Western Pacific Region, Manila, Philippines;1. Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Wangchutaba, Serbithang, Thimphu, Bhutan;2. World Health Organization Consultant, C/Juan de Austria, 13, 28010 Madrid, Spain;3. Ministry of Health, Royal Government of Bhutan, P.O. Box: 726, Kawajangsa, Thimphu, Bhutan;4. Global Immunization Division, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, United States;5. Expanded Programme on Immunization, World Health Organization, 20 Avenue Appia, 1211 Geneva, Switzerland;1. Health Department of the Community of Madrid, Subdirectorate General of Health Promotion and Prevention, Madrid, Spain;2. Health Department of the Community of Madrid, Regional Public Health Laboratory, Madrid, Spain;1. Senior Advisor (Microbiology), Military Hospital Meerut, UP, India;2. Classified Specialist (Medicine), Command Hospital (Southern Command), Pune 411040, India;3. Resident, Dept of Microbiology, Armed Forces Medical College, Pune 411040, India;4. Associate Professor, Dept of Community Medicine, Armed Forces Medical College, Pune 411040, India;1. WHO Country Office, Hanoi, Viet Nam;2. Centers for Disease Control and Prevention, Atlanta, GA, USA;3. National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam |
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| Abstract: | Six hundred and fifty-three teenagers (aged 11-13 year) living in Siena and its surroundings (Tuscany, Italy) were the sample for serological screening intended to ascertain immunity to rubella. It was found that 324 of the teenagers (49.62%) lacked antibodies and, hence, were unprotected against the infection. Out of the 324 girls, 196 (around 3/5) were vaccinated using live vaccine. Post-vaccinal complications, with clinical signs of rubella infection, were recorded in almost one third of the vaccinees. Virus isolation from the blood was, in every case, not possible after either 10 or 30 days from vaccination. The serological findings, expressed in hemagglutination inhibition antibodies, could be summarized in the following way: (i) antibodies at low titre were found in only eight out of 184 girls (4.35%) ten days after vaccination; (ii) serological conversion was recorded in 187 out of 188 girls (99.47%) 30 days after vaccination; (iii) the titres were moderately high but much lower than those recorded for the natural infection. The results are discussed in the context of their implications for the strategies of rubella vaccination as far as the safety and the effectiveness of the vaccine are concerned, with emphasis on the duration of the protective immunity. |
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