1. Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA;2. UPMC Hillman Cancer Center, Pittsburgh, PA, USA;3. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;1. School of Biotechnology and Biomolecular Sciences, UNSW, Sydney, NSW 2052, Australia;2. UNSW RNA Institute, UNSW, Sydney, NSW 2052, Australia;1. Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA;2. Department of Biostatistics and Health Data Science, School of Medicine, Indiana University, Indianapolis, IN, USA;3. Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX, USA;4. Brown Center for Immunotherapy, School of Medicine, Indiana University, Indianapolis, IN, USA;1. Evolutionary Genomics Group, Hospital del Mar Medical Research Institute (IMIM), Barcelona 08003, Spain;1. Dalhousie University, Department of Biology, Halifax, Nova Scotia, Canada;2. Universidade de Campinas, Departamento de Genética, Evolução, Microbiologia e Imunologia, Campinas, SP, Brasil;1. Institute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland;1. CNRS, Université Paris Cité, UPR 9080, Laboratoire de Biochimie Théorique, 13 rue Pierre et Marie Curie, Paris, France;2. Institut Pasteur, Université Paris Cité, Group Fungal Epigenomics, Paris, France
Abstract:
Telomeres are transcribed into long noncoding telomeric repeat-containing RNA (TERRA). Or so we thought. Recently, Al-Turki and Griffith provided evidence that TERRA can code for valine-arginine (VR) or glycine-leucine (GL) dipeptide repeat proteins by undergoing repeat-associated non-ATG (RAN) translation. This finding uncovers a new mechanism by which telomeres can impact cellular function.
