| 嗜黏蛋白阿克曼氏菌治疗疾病的潜力与作用机制研究进展 |
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| 引用本文： | 黄桥深,张永康,汪水平,谭支良,刘勇. 嗜黏蛋白阿克曼氏菌治疗疾病的潜力与作用机制研究进展[J]. 微生物学报, 2023, 63(9): 3360-3373 |
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| 作者姓名： | 黄桥深 张永康 汪水平 谭支良 刘勇 |
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| 作者单位： | 西南大学动物科学技术学院 草食动物科学重庆市重点实验室, 重庆 402460;中国科学院亚热带农业生态研究所 亚热带农业生态过程重点实验室, 湖南 长沙 410125 |
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| 基金项目： | 中国科学院战略性先导科技专项资助(XDA26010301)；国家自然科学基金(31702141)；重庆荣昌农牧高新技术产业研发专项项目(CSTC2020NGZX0007)；广西壮族自治区自然科学基金(2022GXNSFAA035517) |
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| 摘 要： | 嗜黏蛋白阿克曼氏菌(Akkermansia muciniphila, AKK)可促进肠道黏液分泌,维持肠道黏液动态平衡,调节肠黏膜屏障功能,在机体代谢调节、免疫应答中发挥重要作用。AKK对肠道炎症、神经炎症、机体代谢紊乱和癌症等疾病具有显著改善作用,被视为极具潜力的下一代益生菌。本文分别从消化系统、神经系统、代谢性紊乱和癌症等角度入手,系统概述AKK在疾病治疗中的潜力及作用分子机制。
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| 关 键 词： | 嗜黏蛋白阿克曼氏菌 代谢异常 治疗潜力 作用机制 |
| 收稿时间： | 2023-01-04 |
| 修稿时间： | 2023-03-17 |
Potential and mechanism of Akkermansia muciniphila in disease treatment |
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| HUANG Qiaoshen,ZHANG Yongkang,WANG Shuiping,TAN Zhiliang,LIU Yong. Potential and mechanism of Akkermansia muciniphila in disease treatment[J]. Acta microbiologica Sinica, 2023, 63(9): 3360-3373 |
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| Authors: | HUANG Qiaoshen ZHANG Yongkang WANG Shuiping TAN Zhiliang LIU Yong |
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| Affiliation: | Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 402460, China;Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China |
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| Abstract: | Akkermansia muciniphila (AKK) promotes the secretion, maintains the dynamic balance, and regulates the barrier function of intestinal mucus, playing a key role in metabolic regulation and immune response. As a promising next-generation probiotic, AKK can mitigate diseases such as intestinal inflammation, metabolic disorders, neuroinflammation, and cancers. We introduced the therapeutic potential of AKK for diseases of the digestive system, the nervous system, metabolic disorders and cancers, aiming to provide a systematic review of the potential role and molecular mechanism of AKK in disease treatment. |
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| Keywords: | Akkermansia muciniphila metabolic disorders therapeutic potential mechanism |
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