| 乳杆菌胞外多糖合成基因簇及构效关系 |
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| 引用本文： | 石金铭,陈秋羽,刘昭曦,刘双江,陈敏.乳杆菌胞外多糖合成基因簇及构效关系[J].微生物学报,2023,63(9):3482-3499. |
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| 作者姓名： | 石金铭 陈秋羽 刘昭曦 刘双江 陈敏 |
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| 作者单位： | 山东大学微生物技术研究院 微生物国家重点实验室, 山东 青岛 266237 |
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| 基金项目： | 国家重点研发计划(2022YFA1304103)；国家自然科学基金(32070921)；泰山产业领军人才工程专项经费(tscy20200221)；山东省重点研发计划(2020CXGC010601) |
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| 摘 要： | 肠道菌群稳态对维护人体的健康具有至关重要的作用。作为肠道天然微生物群“守卫兵”，益生菌参与改善体内微生态平衡。乳杆菌(Lactobacillus)是一种肠道益生菌的代表，其合成的胞外多糖(exopolysaccharide, EPS)既可通过增益肠道内其他益生菌的生长来优化肠道微生态，还具有抗肿瘤、抗氧化、降胆固醇、降血压和增强机体免疫力等益生功能。本文对近年来乳杆菌胞外多糖的遗传、生物学活性、构效关系等方面的研究进展，进行综述和展望。
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| 关 键 词： | 乳杆菌 胞外多糖 基因簇 多糖结构 构效关系 |
| 收稿时间： | 2023/3/31 0:00:00 |
| 修稿时间： | 2023/6/28 0:00:00 |
Lactobacillus exopolysaccharide:gene clusters for synthesis and structure-activity relationship |
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| SHI Jinming,CHEN Qiuyu,LIU Zhaoxi,LIU Shuangjiang,CHEN Min.Lactobacillus exopolysaccharide:gene clusters for synthesis and structure-activity relationship[J].Acta Microbiologica Sinica,2023,63(9):3482-3499. |
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| Authors: | SHI Jinming CHEN Qiuyu LIU Zhaoxi LIU Shuangjiang CHEN Min |
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| Institution: | State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao 266237, Shandong, China |
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| Abstract: | Intestinal microflora homeostasis plays a crucial role in maintaining human health. As a guard of the natural intestinal microflora, probiotics improve the microecological balance in the host. Lactobacillus is a representative of intestinal probiotics. The exopolysaccharide (EPS) synthesized by Lactobacillus can optimize the intestinal microecology by promoting the growth of other probiotics in the intestine. Moreover, EPS is praised for anti-tumor, antioxidant, cholesterol-lowering, blood pressure-lowering, and immunity-enhancing activities. This article reviews the research progress in the genetics, biological activities, structure-activity relationship of Lactobacillus EPS in recent years. |
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| Keywords: | Lactobacillus exopolysaccharide gene cluster polysaccharide structure structure-activity relationship |
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