Start of life controlled by poly(A) tail-mediated remodeling
Institution:
1. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China;2. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA;3. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;4. Howard Hughes Medical Institute, MA, USA;5. Harvard Stem Cell Institute, 200 Longwood Avenue, Boston, MA 02115, USA;1. Université Côte d’Azur, Institute of Research on Cancer and Aging in Nice (IRCAN), Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération Hospitalo-Universitaire (FHU) OncoAge, F-06189 Nice, France;2. University Côte d’Azur, Centre Antoine Lacassagne, Epidemiology and Biostatistics Department, 33 avenue de Valombrose, F-06189 Nice, France;3. Université Côte d’Azur, Centre Hospitalier Universitaire (CHU) de Nice, Laboratory of Clinical and Experimental Pathology, FHUOncoAge, Hospital-Integrated Biobank (BB-0033-00025), F-06001 Nice, France;4. Centre Antoine Lacassagne, Service de Valorisation Scientifique, F-06100 Nice, France;1. Vita-Salute San Raffaele University, Milan, Italy;2. Sleep Disorders Center, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy;3. Seattle Children’s Hospital and University of Washington, Seattle, WA, USA;4. Developmental and Social Psychology, Sapienza University of Rome, Rome, Italy;5. Oasi Research Institute – IRCCS, Troina, Italy;6. Institute of Molecular Bioimaging and Physiology, National Research Council, Milan, Italy;7. Institute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, Italy;1. Dalhousie University, Department of Biology, Halifax, Nova Scotia, Canada;2. Universidade de Campinas, Departamento de Genética, Evolução, Microbiologia e Imunologia, Campinas, SP, Brasil;1. Institute of Genomics, School of Medicine, Huaqiao University, 668 Jimei Road, Xiamen 361021, China;1. Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S3B2, Canada
Abstract:
Understanding a remarkable event at the start of life, the oocyte-to-embryo transition (OET), has remained elusive, especially in humans. Using newly developed techniques, Liu et al. showed that human maternal mRNAs undergo global poly(A) tail-mediated remodeling during OET, identified the enzymes involved, and demonstrated the essentiality of remodeling for embryo cleavage.
