The role of ferroptosis in metabolic diseases |
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| Affiliation: | 1. Division of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad 10066, Iraq;2. Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq;3. Department of Pharmacy, Al-Mustaqbal University College, Babylon, Iraq;4. Department of Dentistry, Al-Farahidi University, Baghdad, Iraq;5. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Qassim 51452, Kingdom of Saudi Arabia;6. Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt;1. Department of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu Province, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China;2. Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China;3. Child Mental Health Research Center, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China;4. Institute for Stem Cell and Neural Regeneration, State Key Laboratory of Reproductive Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, China;1. Advanced Research Facilities & Services, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan;2. Department of Molecular Biology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan;3. Laboratory Animal Facilities & Services, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan;4. Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki-City, Miyazaki 889-1692, Japan;5. Laboratory of Genome Stress Signaling, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan;1. College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, PR China;2. State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, PR China;1. Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan;2. Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan;3. Department of Medical Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan;4. AMED-CREST, Japan Agency for Medical Research and Development (AMED), Tokyo 100-0004, Japan |
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| Abstract: | The annual incidence of metabolic diseases such as diabetes, non-alcoholic fatty liver disease (NAFLD), osteoporosis, and atherosclerosis (AS) is increasing, resulting in a heavy burden on human health and the social economy. Ferroptosis is a novel form of programmed cell death driven by iron-dependent lipid peroxidation, which was discovered in recent years. Emerging evidence has suggested that ferroptosis contributes to the development of metabolic diseases. Here, we summarize the mechanisms and molecular signaling pathways involved in ferroptosis. Then we discuss the role of ferroptosis in metabolic diseases. Finally, we analyze the potential of targeting ferroptosis as a promising therapeutic approach for metabolic diseases. |
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