Exclusive Decoration of Simian Immunodeficiency Virus Env with High-Mannose Type N-Glycans Is Not Compatible with Mucosal Transmission in Rhesus Macaques |
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| Authors: | Christina B Karsten Falk F R Buettner Samanta Cajic Inga Nehlmeier Berit Neumann Antonina Klippert Ulrike Sauermann Udo Reichl Rita Gerardy-Schahn Erdmann Rapp Christiane Stahl-Hennig Stefan P?hlmann |
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| Institution: | aInstitute for Cellular Chemistry, Hannover Medical School, Hannover, Germany;bInfection Biology Unit, German Primate Center, Göttingen, Germany;cMax-Planck-Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany;dUnit of Infection Models, German Primate Center, Göttingen, Germany;eglyXera GmbH, Magdeburg, Germany |
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| Abstract: | Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SIV Env with these N-glycans reduces viral infectivity and abrogates mucosal transmission, despite increasing viral capture by immune cell lectins. Thus, high-mannose N-glycans have opposed effects on SIV infectivity and lectin reactivity, and a balance might be required for efficient mucosal transmission. |
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