Organ-on-a-chip models for elucidating the cellular biology of infectious diseases |
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| Affiliation: | 1. Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan;2. Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan;3. Department of Medical Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan;4. AMED-CREST, Japan Agency for Medical Research and Development (AMED), Tokyo 100-0004, Japan;1. Advanced Research Facilities & Services, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan;2. Department of Molecular Biology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan;3. Laboratory Animal Facilities & Services, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan;4. Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki-City, Miyazaki 889-1692, Japan;5. Laboratory of Genome Stress Signaling, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan;1. Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, Paschim Medinipur 721140, West Bengal, India;2. PanTherapeutics, Rte de Lavaux 49, CH1095 Lutry, Switzerland;3. Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB, India;4. Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil;5. Department of Biological Sciences (DCB), Graduate Program in Genetics and Molecular Biology (PPGGBM), State University of Santa Cruz (UESC), Rodovia Ilheus-Itabuna, km 16, 45662-900 Ilheus, BA, Brazil;6. Laboratory of Bioinformatics and Computational Chemistry, Department of Biological Sciences, State University of Southwest Bahia (UESB), Jequié 45206-190, Brazil;7. Laborat''orio de Geńetica Celular e Molecular, Departamento de Genetica, Ecologia e Evolucao, Instituto de Ciˆencias Biol''ogicas, Universidade Federal de Minas Gerais, Belo Horizonte CEP 31270-901, Brazil;8. Applied Statistics Unit, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India;9. Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy;10. Department of Physiology, Michigan State University, East Lansing, MI 48824, USA;11. Applied Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, India;12. Department of Biochemistry, Kakatiya Medical College, Warangal, Telangana, India;13. Doctoral Studies in Natural and Technical Sciences (SPL 44), University of Vienna, W¨ahringer Straße, A-1090 Vienna, Austria;14. Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA;15. Department of Environmental Health Sciences, Tulane University, New Orleans, LA 70112, USA;p. Department of Zoology, Patna University, Patna, Bihar, India;q. Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University, Faculty of Pharmacy, Irbid 566, Jordan;r. University of Pittsburgh School of Medicine, Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA;s. Biomaterials and Bioengineering Lab, Centro de Investigaci''on Traslacional San Alberto Magno, Universidad Cat́olica de Valencia San Vicente Ḿartir, c/Guillem de Castro, 94, 46001 Valencia, Spain;t. Department of Food Science, University of Otago, Dunedin 9054, New Zealand;u. Zoology Department, Faculty of Science, Minia University, El-Minia 61519, Egypt;v. Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA;w. Faculty of Science, Department of Biological Science, King Abdulazizi University, Jeddah 21589, Saudi Arabia;x. Therapeutic and Protective Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technology Applications, New Borg El-Arab, Alexandria 21934, Egypt;y. Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan;z. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;11. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden;12. School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK;13. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA;14. Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy pereulok, 9, Dolgoprudny, 141700, Russia;1. Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, Paschim Medinipur 721140, West Bengal, India;2. PanTherapeutics, Rte de Lavaux 49, CH1095 Lutry, Switzerland;3. Biomaterials and Bioengineering Lab, Centro de Investigacion Traslacional San Alberto Magno, Universidad Catolica de Valencia San Vicente Martir, c/Guillem de Castro, 94, 46001 Valencia, Valencia, Spain;4. Department of Food Science, University of Otago, Dunedin 9054, New Zealand;5. Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University, Faculty of Pharmacy, Irbid 566, Jordan;6. Biological Science Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia;7. Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA;8. Applied Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana, India;9. Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229-3900, USA;10. Indian Statistical Institute, Applied Statistics Unit, 203 B T Road, Kolkata 700108, India;11. Department of Zoology, Patna University, Patna, Bihar, India;12. Department of Environmental Health Sciences, Tulane University, New Orleans, LA, 70112, USA;13. School of Engineering and Sciences, Tecnologico de Monterrey, 64849 Monterrey, Nuevo Leon, Mexico;14. School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK;15. Center for iPS Cell Research and Application, Kyoto University, Kyoto 6068507, Japan;p. Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur 721172, West Bengal, India;q. Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy;r. School of Physics, University of the Witwatersrand, Johannesburg, Braamfontein 2000, 721140, South Africa;s. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA;t. Therapeutic and Protective Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, New Borg EL-Arab 21934, Alexandria, Egypt;u. Department of Biocemistry, Kakatiya Medical College, Warangal, Telangana, India;v. Zoology Department, Faculty of Science, Minia University, El-Minia 61519, Egypt;w. Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil |
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| Abstract: | Infectious diseases are caused by the invasion of pathogens into a host. To explore the mechanisms of pathogen infections and cellular responses, human models that can accurately recapitulate human pathophysiology are needed. Organ-on-a-chip is a type of advanced in vitro model system that cultures cells in microfluidic devices to replicate physiologically relevant microenvironments such as 3D structures, shear stress, and mechanical stimulation. Recently, organ-on-a-chips have been widely adopted to examine the pathophysiology of infectious diseases in detail. Here, we will summarize recent advances in infectious disease research of visceral organs such as the lung, intestine, liver, and kidneys, using organ-on-a-chips. |
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