Production of octadecylphospho-l-serine by phospholipase d |
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Authors: | I Aurich P Dürrschmidt A Schierhorn R Ulbrich-Hofmann |
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Institution: | (1) Department of Biochemistry/Biotechnology, Martin-Luther, University Halle-Wittenberg, D-06099 Halle, Germany |
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Abstract: | Octadecylphospho-l-serine (OPS), belonging to the family of alkylphosphate esters with anticancer activity, was synthesized by transesterification of octadecylphosphocholine using phospholipase d (PLD). With respect to the yield of product, PLD from cabbage proved to be superior to PLD from Streptomyces spp. Although the addition of n-hexane/2-octanol is advantageous to suppress the hydrolytic byproduct, a purely aqueous reaction medium was preferred because of better recovery of the product. |
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Keywords: | alkylphosphate esters alkylphospholipids enzymatic transesterification octadecylphospho-l-serine phospholipase d |
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