Effect of vitamin E-deficiency on the activity of some lysosomal and non-lysosomal proteases in rabbit muscles. |
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Authors: | G Katona V Székessy-Hermann F Guba I Sohár |
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Institution: | 2nd Institute of Biochemistry, Semmelweis University Medical School, Budapest, Hungary. |
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Abstract: | The activity of different cathepsins and neutral proteinases was measured in normal and vitamin E-deficient rabbit muscles using specific substrates. Among the changes of enzyme activities in dystrophy caused by vitamin E-deficiency the increase in the activity of cathepsin B is the most striking. The activity of cathepsin H, both in the fast and slow muscles and that of MMP-ase in the slow muscle remains practically unchanged. Activities of other proteases significantly increase. The change in the activity of proteolytic enzymes in striated muscle of vitamin E-deficient rabbits seems to be selective. As a rule the increase in the activity is higher in fast than in slow muscles. |
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