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Systemic effect of chitin after intravenous administration to dogs |
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| Authors: | S. Minami R. Mura-e Y. Okamoto T. Sanekata A. Matsuhashi S. Tanioka Y. Shigemasa |
| Affiliation: | a Department of Veterinary Surgery, Faculty of Agriculture, Tottori University, Tottori 680, Japan b Department of Veterinary Microbiology, Faculty of Agriculture, Tottori University, Tottori 680, Japan c Sunfive Co. Ltd., Koyama-cho, Tottori 680, Japan d Department of Materials Sciences, Faculty of Engineering, Tottori University, Tottori 680, Japan |
| Abstract: | The systemic effect of chitin and chitin oligomer after intravenous administration was investigated in dogs by determining the chemiluminescence (CL) response and the white blood cell count (WBC). Chitin oligomer (2mg/kg) and physiological saline (5ml) did not have a systemic effect. However, in the dogs injected with chitin, WBC decreased significantly from 1 to 4 h after injection and then increased gradually to 1.4 times the pre-injection level at 72 h, while CL was significantly increased 1–2 h after injection. |
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