Progesterone reduces erectile dysfunction in sleep-deprived spontaneously hypertensive rats |
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| Authors: | Monica L Andersen Raquel CS Martins Tathiana AF Alvarenga Isabela B Antunes Ligia A Papale and Sergio Tufik |
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| Institution: | (1) Psychobiology Department, Universidade Federal de S?o Paulo, Escola Paulista de Medicina (UNIFESP/EPM), R. Napole?o de Barros, 925 V. Clementino, 04024-002 S?o Paulo, SP, Brazil |
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| Abstract: | Background Paradoxical sleep deprivation (PSD) associated with cocaine has been shown to enhance genital reflexes (penile erection-PE
and ejaculation-EJ) in Wistar rats. Since hypertension predisposes males to erectile dysfunction, the aim of the present study
was to investigate the effects of PSD on genital reflexes in the spontaneously hypertensive rat (SHR) compared to the Wistar
strain. We also extended our study to examine how PSD affect steroid hormone concentrations involved in genital events in
both experimental models. |
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