Intranasal Administration of Nerve Growth Factor Produces Antidepressant-Like Effects in Animals |
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Authors: | Cui-ge Shi Lu-ming Wang Ying Wu Peng Wang Zhu-jun Gan Kai Lin Li-xin Jiang Zhi-qing Xu Ming Fan |
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Institution: | (1) Department of Neurobiology, Capital Medical University, Beijing, China;(2) Department of Brain Protection and Plasticity, Institute of Basic Medical Sciences, 27 Taiping Road, 100850 Beijing, China;(3) Clinic Laboratory Center, Air Force Genneral Hospital, Beijing, China;(4) Staison Bio-Pharmaceutical Company, Beijing, China; |
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Abstract: | Many works showed that nerve growth factor (NGF) injected into the brain of animal model emerges potential antidepressant
effects. However, this route of administration significantly restricts the application of NGF clinically. Here, we reported
that intranasal NGF could provide an alternative to intraventricular injection. The behavioral analysis showed that intranasal
administration of NGF reduced the immobility time in forced swimming test (FST) and tail suspension test (TST) in mice. Likewise,
intranasal NGF increased the sucrose intake and the locomotor activity in rats after unpredictable chronic mild stress (UCMS).
Furthermore, intranasal NGF increased the levels of monoamine neurotransmitters (norepinephrine, dopamine) in the frontal
cortex and hippocampus and affected the number of 5-bromodeoxyuridine (BrdU), c-fos and caspase-3 positive neurons in dentate
gyrus of hippocampus in rats after UCMS. In summary, intranasal NGF had significant antidepressant effects on animal models
of depression and this route of administration may provide a promising way to deliver NGF to brain in a therapeutic perspective. |
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