IGFBP-3 Inhibits the Proliferation of Neural Progenitor Cells |
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Authors: | Haviryaji S G Kalluri Robert J Dempsey |
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Institution: | (1) Department of Neurosurgery, University of Wisconsin, Madison, WI 53792, USA;(2) Department of Neurosurgery and Cardiovascular Research Center, University of Wisconsin, Madison, WI 53792, USA |
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Abstract: | Insulin like growth factor-1 (IGF-1) plays an important role in the proliferation and differentiation of neural progenitor
cells. The effects of IGF-1 can be regulated by insulin like growth factor binding protein-3 (IGFBP-3) which can either inhibit
or stimulate the proliferation of cells depending on the expression of proteases that can release IGF-1 from IGF1-IGFBP3 complex.
Although IGF-1 is essential for the development of brain, both IGFBP-3 and IGF-1 are elevated in the brains of children younger
than 6 months of age. Likewise, IGFBP-3 is also upregulated following cerebral ischemia and hypoxia. However, the role of
IGFBP-3 in neurogenesis is not clear. Using an in vitro culture system of rat neural progenitor cells, we demonstrate that
IGFBP-3 specifically regulates the IGF-1 mediated neural progenitor cell proliferation via down regulation of phopho-Akt,
and cyclin D1. In addition, IGFBP-3 also decreased the content of nestin in the neural progenitor cells indicating its potential
role in neurogenesis. |
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Keywords: | |
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