GuiTope: an application for mapping random-sequence peptides to protein sequences |
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Authors: | Rebecca F Halperin Phillip Stafford Jack S Emery Krupa Arun Navalkar and Stephen Albert Johnston |
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Institution: | (1) Center for Innovations in Medicine, The Biodesign Institute at Arizona State University, PO Box 875901, Tempe, AZ 85281, USA |
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Abstract: | Background Random-sequence peptide libraries are a commonly used tool to identify novel ligands for binding antibodies, other proteins,
and small molecules. It is often of interest to compare the selected peptide sequences to the natural protein binding partners
to infer the exact binding site or the importance of particular residues. The ability to search a set of sequences for similarity
to a set of peptides may sometimes enable the prediction of an antibody epitope or a novel binding partner. We have developed
a software application designed specifically for this task. |
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Keywords: | |
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