The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction |
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| Authors: | Jung-Ho Yoon Song Her Moonhee Kim Ik-Soon Jang Junsoo Park |
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| Institution: | (1) Division of Biological Science and Technology, Yonsei University, Wonju, 220-710, Republic of Korea;(2) Korea Basic Science Institute, Chuncheon Center, Chuncheon, 200-701, Republic of Korea;(3) Division of Life Science, Korea Basic Science Institute, Daejeon, 305-333, Republic of Korea;(4) Division of Biological Sciences and Technology, Yonsei Institute of Space Bioscience, Yonsei University, 1 Yonseidae-gil, Wonju, 220-710, Republic of Korea; |
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| Abstract: | Autophagy is a membrane trafficking process involved in intracellular degradation and recycling in eukaryotic cells. DRAM2
(damage-regulated autophagy modulator 2) is a homologue of DRAM that regulates p53-mediated cell death. As its name implies,
DRAM expression induces autophagy in a p53-dependent manner; however, the role of DRAM2 in autophagy is not clear. In this
study, we report that DRAM2 expression contributes to autophagy induction. Overexpression of DRAM2 induces cytoplasmic GFP-LC3
punctuates, and increases the level of endogenous LC3-II. Moreover, the silencing of endogenous DRAM2 interferes with starvation-induced
autophagy. Thus, we propose that DRAM2 as well as DRAM are involved in autophagy. |
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