Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population |
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Authors: | Vita Ignatovica Gustavs Latkovskis Raitis Peculis Kaspars Megnis Helgi B Schioth Iveta Vaivade Davids Fridmanis Valdis Pirags Andrejs Erglis Janis Klovins |
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Institution: | (1) Latvian Biomedical Research and Study Centre, Ratsupites str. 1, Riga, 1067, Latvia;(2) Latvian Research Institute of Cardiology, University of Latvia, Sarlotes iela 1a, Riga, LV, 1001, Latvia;(3) Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, BOX 593, 751 24 Uppsala, Sweden;(4) Centre of Cardiology, Pauls Stradins Clinical University Hospital, Pilsonu iela 13, Riga, LV, 1002, Latvia;(5) Faculty of Medicine, University of Latvia, Sarlotes iela 1a, Riga, LV, 1001, Latvia;(6) Department of Endocrinology, Pauls Stradins Clinical University Hospital, Pilsonu iela 13, Riga, LV, 1002, Latvia |
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Abstract: | The purinergic 1 receptor (P2RY1) has been implicated in development of heart disease and in individual pharmacodynamic response
to anticoagulant therapies. However, the association of polymorphisms in the P2RY1 gene with myocardial infarction (MI), and
its associated conditions, has yet to be reported in the literature. We evaluated seven known SNPs in P2RY1 for association
with MI in a Latvian population. Seven independent parameters that are related to MI body mass index (BMI), type 2 diabetes
(T2D), angina pectoris, hypertension, hyperlipidemia, atrial fibrillation and heart failure] were investigated. No significant
association with MI was observed for any of the polymorphisms. Those SNPs for which the P value was close to significance were located in coding or promoter regions. Intriguingly, carriers of the minor allele in
the P2RY1 gene locus showed a tendency towards higher onset age for MI, suggesting a possible protective effect of these SNPs
against MI or their contribution in progression as opposed to onset. Finally, a linkage disequilibrium (LD) plot was generated
for these polymorphisms in the Latvian population. The results of this study suggest that the role of P2RY1 in individuals
from Latvian population is likely to be principally involved in platelet aggregation and thromboembolic diseases, and not
as a significant contributing factor to the global metabolic syndrome. |
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