Caffeic Acid Phenethyl Ester Modulates Gentamicin-Induced Oxidative Nephrotoxicity in Kidney of Rats |
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Authors: | Fadime Özge Aygün Füsun Zeynep Akçam Onur Kaya Betül Mermi Ceyhan Recep Sütçü |
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Institution: | 1.Department of Infectious Diseases, Faculty of Medicine,Süleyman Demirel University,Isparta,Turkey;2.Department of Biochemistry and Clinical Biochemistry, Faculty of Medicine,Süleyman Demirel University,Isparta,Turkey |
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Abstract: | In this study, the modulator effect of caffeic acid phenethyl ester (CAPE) on the oxidative nephrotoxicity of gentamicin in
the kidneys of rats was investigated by determining indices of lipid peroxidation and the activities of antioxidant enzymes
as well as by histological analyses. Forty female Wistar albino rats were randomly divided into four groups, namely control,
gentamicin, CAPE, and gentamicin plus CAPE. On the 12th day of the study, all rats were sacrificed and then blood samples
and kidneys were taken. Lipid peroxidation and nitric oxide levels, glutathione peroxidase (GSH-Px), superoxide dismutase
(SOD) and catalase (CAT) enzyme activities, and histological evaluation were measured in kidneys of rats. Levels of blood
urea nitrogen and creatinine were studied in serum. CAPE with gentamicin caused decreases in lipid peroxidation, nitric oxide,
urea nitrogen, and creatinine levels, although it caused increases in CAT, GSH-Px, and SOD activities when compared with gentamicin
alone. In addition, on histological evaluation, the renal damage caused by gentamicin alone appeared much higher than that
caused by CAPE plus gentamicin. It is concluded that oxidative stress plays a critical role in causing gentamicin nephrotoxicity
and that this nephrotoxicity may be significantly reduced by CAPE. |
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