Effect of cytochalasin B and colchicine on the stimulation of -amylase release from rat parotid tissue slices |
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Authors: | F R Butcher R H Goldman |
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Institution: | Division of Biological and Medical Sciences Brown University, Providence, Rhode Island 02912 USA |
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Abstract: | A role for microfilaments and microtubules in the secretion of α-amylase is indicated since cytochalasin B and colchicine inhibited the stimulation of α-amylase release by epinephrine (30 or 15 μM) but only cytochalasin B inhibited the stimulation by N6, O2′ dibutyryl adenosine 3′,5′monophosphate (1.0 mM). It was necessary to incubate the parotid tissue slices in the presence of cytochalasin B (1 hr.) or colchicine (4 hrs.) before adding the agonist in order to see the inhibitory effects. |
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