Multiple roles for basement membrane proteins in cancer progression and EMT |
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| Affiliation: | 1. Shri Shikshayatan College, Kolkata, West Bengal, India;2. Department of Surgery, Division of Neurosurgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan;3. Department of Neurosurgery, Taipei Medical University Hospital, Taipei 11031, Taiwan;4. Taipei Neuroscience Institute, Taipei Medical University, Taipei 11031, Taiwan;5. PG Department of Botany, Lady Brabourne College, Kolkata, West Bengal, India;6. Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, West Bengal, India;7. Smt. N. M. Padalia Pharmacy College, Ahmedabad, Gujarat, India;8. Department of Biotechnology, ARKA Jain University, Jamshedpur 831005, India;9. Plant Biotechnology Unit, KM Government Institute for Postgraduate Studies and Research, Puducherry, India;10. Sangola College, Sangola District, Solapur, Maharashtra, India;11. Department of Biochemistry, Mus Alparslan University, Turkey;12. Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia;13. Victory Biotechnology Co., Ltd., Taipei 114757, Taiwan;14. ShiNeo Technology Co., Ltd., New Taipei City 24262, Taiwan;15. Department of Life Science, School of Basic Science and Research, Sharda University, Knowledge Park-III, Greater Noida, UP 201310, India;p. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al-Majmaah 11952, Saudi Arabia;q. Center of Research for Development (CR4D), Parul Institute of Applied Sciences (PIAS), PO Limda, Tal Waghodia 391760, Vadodara, Gujarat, India;r. Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida 201310, India;s. ER stress and Mucosal immunology lab, School of Health Sciences, University of Tasmania, Launceston, Tasmania 7248, Australia |
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| Abstract: | Metastasis or the progression of malignancy poses a major challenge in cancer therapy and is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) of the basement membrane (BM) allows cells of epithelial phenotype to transform into a mesenchymal-like (quasi-mesenchymal) phenotype and metastasize via the lymphovascular system through a metastatic cascade by intravasation and extravasation. This helps in the progression of carcinoma from the primary site to distant organs. Collagen, laminin, and integrin are the prime components of BM and help in tumor cell metastasis, which makes them ideal cancer drug targets. Further, recent studies have shown that collagen, laminin, and integrin can be used as a biomarker for metastatic cells. In this review, we have summarized the current knowledge of such therapeutics, which are either currently in preclinical or clinical stages and could be promising cancer therapeutics.Data availabilityNot applicable |
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| Keywords: | Basement membrane EMT Metastasis Collagen Laminin Integrin |
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