The mammalian endocytic cytoskeleton |
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Affiliation: | 1. Helsinki Institute of Life Science, HiLIFE, Viikinkaari 5, 00790 Helsinki, Finland;2. Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 5, 00790 Helsinki, Finland;3. Institute of Biotechnology, Viikinkaari 5, 00790 Helsinki, Finland |
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Abstract: | Clathrin-mediated endocytosis (CME) is the major route through which cells internalise various substances and recycle membrane components. Via the coordinated action of many proteins, the membrane bends and invaginates to form a vesicle that buds off—along with its contents—into the cell. The contribution of the actin cytoskeleton to this highly dynamic process in mammalian cells is not well understood. Unlike in yeast, where there is a strict requirement for actin in CME, the significance of the actin cytoskeleton to mammalian CME is variable. However, a growing number of studies have established the actin cytoskeleton as a core component of mammalian CME, and our understanding of its contribution has been increasing at a rapid pace. In this review, we summarise the state-of-the-art regarding our understanding of the endocytic cytoskeleton, its physiological significance, and the questions that remain to be answered. |
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Keywords: | Receptor-mediated endocytosis Cytoskeleton Endocytic cytoskeleton Actin regulation Membrane bending FCHSD2 |
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